Description
Neurexin-3-beta, also known as Neurexin III-beta and NRXN3, is a single-pass type I membrane protein that belongs to the neurexin family. It contains one laminin G-like domain. It is a neuronal cell surface protein that may be involved in cell recognition and cell adhesion. Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1, NRXN2, NRXN3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain EGF-like sequences and laminin G domains and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. NRXN3 has been linked to a genetic predisposition towards some conditions such as alcohol or drug addiction, or obesity.
This Human NRXN3 overexpression lysate was created in HEK293 Cells and intented for use as a Western blot (WB) positive control. Purification of NRXN3 protein from the overexpression lysate was verified